CovidFranceV1, Main, Exploration, bibRecord, 000E33

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.

Identifieur interne : 000E33 ( Main/Exploration ); précédent : 000E32; suivant : 000E34

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.

Auteurs : Julie Helms [France] ; Charles Tacquard [France] ; François Severac [France] ; Ian Leonard-Lorant [France] ; Mickaël Ohana [France] ; Xavier Delabranche [France] ; Hamid Merdji [France] ; Raphaël Clere-Jehl [France] ; Malika Schenck [France] ; Florence Fagot Gandet [France] ; Samira Fafi-Kremer [France] ; Vincent Castelain [France] ; Francis Schneider [France] ; Lélia Grunebaum [France] ; Eduardo Anglés-Cano [France] ; Laurent Sattler [France] ; Paul-Michel Mertes [France] ; Ferhat Meziani [France]

Source :

Intensive care medicine [ 1432-1238 ] ; 2020.

RBID : pubmed:32367170

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Anticoagulants (usage thérapeutique), Betacoronavirus (pathogénicité), Embolie pulmonaire (complications), Embolie pulmonaire (mortalité), Embolie pulmonaire (physiopathologie), Embolie pulmonaire (virologie), Femelle (MeSH), France (épidémiologie), Humains (MeSH), Infections à coronavirus (mortalité), Infections à coronavirus (physiopathologie), Infections à coronavirus (thérapie), Maladie grave (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (physiopathologie), Pneumopathie virale (thérapie), Produits de dégradation de la fibrine et du fibrinogène (analyse), Produits de dégradation de la fibrine et du fibrinogène (métabolisme), Score de propension (MeSH), Sujet âgé (MeSH), Syndrome respiratoire aigu sévère (complications), Syndrome respiratoire aigu sévère (mortalité), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Thrombose (mortalité), Thrombose (physiopathologie), Thrombose (virologie), Thrombose (étiologie), Unités de soins intensifs (MeSH), Études prospectives (MeSH).
MESH :
- analyse : Produits de dégradation de la fibrine et du fibrinogène.
- mortalité : Embolie pulmonaire, Infections à coronavirus, Pneumopathie virale, Syndrome respiratoire aigu sévère, Thrombose.
- métabolisme : Embolie pulmonaire, Produits de dégradation de la fibrine et du fibrinogène, Syndrome respiratoire aigu sévère.
- pathogénicité : Betacoronavirus.
- physiopathologie : Embolie pulmonaire, Infections à coronavirus, Pneumopathie virale, Syndrome respiratoire aigu sévère, Thrombose.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Anticoagulants.
- virologie : Embolie pulmonaire, Syndrome respiratoire aigu sévère, Thrombose.
- épidémiologie : France.
- étiologie : Thrombose.
- Adulte d'âge moyen, Femelle, Humains, Maladie grave, Mâle, Pandémies, Score de propension, Sujet âgé, Unités de soins intensifs, Études prospectives.
Wicri :
- geographic : France.

English descriptors

KwdEn :
- Aged (MeSH), Anticoagulants (therapeutic use), Betacoronavirus (pathogenicity), Coronavirus Infections (mortality), Coronavirus Infections (physiopathology), Coronavirus Infections (therapy), Critical Illness (MeSH), Female (MeSH), Fibrin Fibrinogen Degradation Products (analysis), Fibrin Fibrinogen Degradation Products (metabolism), France (epidemiology), Humans (MeSH), Intensive Care Units (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (mortality), Pneumonia, Viral (physiopathology), Pneumonia, Viral (therapy), Propensity Score (MeSH), Prospective Studies (MeSH), Pulmonary Embolism (complications), Pulmonary Embolism (mortality), Pulmonary Embolism (physiopathology), Pulmonary Embolism (virology), Severe Acute Respiratory Syndrome (complications), Severe Acute Respiratory Syndrome (mortality), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (virology), Thrombosis (etiology), Thrombosis (mortality), Thrombosis (physiopathology), Thrombosis (virology).
MESH :
- chemical , analysis : Fibrin Fibrinogen Degradation Products.
- chemical , metabolism : Fibrin Fibrinogen Degradation Products.
- chemical , therapeutic use : Anticoagulants.
- geographic , epidemiology : France.
- complications : Pulmonary Embolism, Severe Acute Respiratory Syndrome.
- etiology : Thrombosis.
- mortality : Coronavirus Infections, Pneumonia, Viral, Pulmonary Embolism, Severe Acute Respiratory Syndrome, Thrombosis.
- pathogenicity : Betacoronavirus.
- physiopathology : Coronavirus Infections, Pneumonia, Viral, Pulmonary Embolism, Severe Acute Respiratory Syndrome, Thrombosis.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- virology : Pulmonary Embolism, Severe Acute Respiratory Syndrome, Thrombosis.
- Aged, Critical Illness, Female, Humans, Intensive Care Units, Male, Middle Aged, Pandemics, Propensity Score, Prospective Studies.

Abstract

PURPOSE

Little evidence of increased thrombotic risk is available in COVID-19 patients. Our purpose was to assess thrombotic risk in severe forms of SARS-CoV-2 infection.

METHODS

All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrome (ARDS) due to COVID-19 between March 3rd and 31st 2020 were included. Medical history, symptoms, biological data and imaging were prospectively collected. Propensity score matching was performed to analyze the occurrence of thromboembolic events between non-COVID-19 ARDS and COVID-19 ARDS patients.

RESULTS

150 COVID-19 patients were included (122 men, median age 63 [53; 71] years, SAPSII 49 [37; 64] points). Sixty-four clinically relevant thrombotic complications were diagnosed in 150 patients, mainly pulmonary embolisms (16.7%). 28/29 patients (96.6%) receiving continuous renal replacement therapy experienced circuit clotting. Three thrombotic occlusions (in 2 patients) of centrifugal pump occurred in 12 patients (8%) supported by ECMO. Most patients (> 95%) had elevated D-dimer and fibrinogen. No patient developed disseminated intravascular coagulation. Von Willebrand (vWF) activity, vWF antigen and FVIII were considerably increased, and 50/57 tested patients (87.7%) had positive lupus anticoagulant. Comparison with non-COVID-19 ARDS patients (n = 145) confirmed that COVID-19 ARDS patients (n = 77) developed significantly more thrombotic complications, mainly pulmonary embolisms (11.7 vs. 2.1%, p < 0.008). Coagulation parameters significantly differed between the two groups.

CONCLUSION

Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore probably be suggested.

DOI: 10.1007/s00134-020-06062-x
PubMed: 32367170
PubMed Central: PMC7197634

Affiliations:

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Le document en format XML

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<author><name sortKey="Fafi Kremer, Samira" sort="Fafi Kremer, Samira" uniqKey="Fafi Kremer S" first="Samira" last="Fafi-Kremer">Samira Fafi-Kremer</name>
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<author><name sortKey="Castelain, Vincent" sort="Castelain, Vincent" uniqKey="Castelain V" first="Vincent" last="Castelain">Vincent Castelain</name>
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<author><name sortKey="Schneider, Francis" sort="Schneider, Francis" uniqKey="Schneider F" first="Francis" last="Schneider">Francis Schneider</name>
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<author><name sortKey="Grunebaum, Lelia" sort="Grunebaum, Lelia" uniqKey="Grunebaum L" first="Lélia" last="Grunebaum">Lélia Grunebaum</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Angles Cano, Eduardo" sort="Angles Cano, Eduardo" uniqKey="Angles Cano E" first="Eduardo" last="Anglés-Cano">Eduardo Anglés-Cano</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Innovative Therapies in Haemostasis, INSERM UMR_S 1140, Université de Paris, 75006, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
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<author><name sortKey="Sattler, Laurent" sort="Sattler, Laurent" uniqKey="Sattler L" first="Laurent" last="Sattler">Laurent Sattler</name>
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<author><name sortKey="Mertes, Paul Michel" sort="Mertes, Paul Michel" uniqKey="Mertes P" first="Paul-Michel" last="Mertes">Paul-Michel Mertes</name>
<affiliation wicri:level="3"><nlm:affiliation>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
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<settlement type="city">Strasbourg</settlement>
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<author><name sortKey="Meziani, Ferhat" sort="Meziani, Ferhat" uniqKey="Meziani F" first="Ferhat" last="Meziani">Ferhat Meziani</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex, France. Ferhat.Meziani@chru-strasbourg.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
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<settlement type="city">Strasbourg</settlement>
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<affiliation wicri:level="3"><nlm:affiliation>UMR 1260, Regenerative Nanomedicine (RNM), FMTS, INSERM (French National Institute of Health and Medical Research), Strasbourg, France. Ferhat.Meziani@chru-strasbourg.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR 1260, Regenerative Nanomedicine (RNM), FMTS, INSERM (French National Institute of Health and Medical Research), Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
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<idno type="doi">10.1007/s00134-020-06062-x</idno>
<idno type="pmc">PMC7197634</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.</title>
<author><name sortKey="Helms, Julie" sort="Helms, Julie" uniqKey="Helms J" first="Julie" last="Helms">Julie Helms</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tacquard, Charles" sort="Tacquard, Charles" uniqKey="Tacquard C" first="Charles" last="Tacquard">Charles Tacquard</name>
<affiliation wicri:level="3"><nlm:affiliation>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Severac, Francois" sort="Severac, Francois" uniqKey="Severac F" first="François" last="Severac">François Severac</name>
<affiliation wicri:level="3"><nlm:affiliation>Groupe Méthodes en Recherche Clinique (GMRC), Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Groupe Méthodes en Recherche Clinique (GMRC), Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leonard Lorant, Ian" sort="Leonard Lorant, Ian" uniqKey="Leonard Lorant I" first="Ian" last="Leonard-Lorant">Ian Leonard-Lorant</name>
<affiliation wicri:level="3"><nlm:affiliation>Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ohana, Mickael" sort="Ohana, Mickael" uniqKey="Ohana M" first="Mickaël" last="Ohana">Mickaël Ohana</name>
<affiliation wicri:level="3"><nlm:affiliation>Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delabranche, Xavier" sort="Delabranche, Xavier" uniqKey="Delabranche X" first="Xavier" last="Delabranche">Xavier Delabranche</name>
<affiliation wicri:level="3"><nlm:affiliation>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Merdji, Hamid" sort="Merdji, Hamid" uniqKey="Merdji H" first="Hamid" last="Merdji">Hamid Merdji</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>UMR 1260, Regenerative Nanomedicine (RNM), FMTS, INSERM (French National Institute of Health and Medical Research), Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR 1260, Regenerative Nanomedicine (RNM), FMTS, INSERM (French National Institute of Health and Medical Research), Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clere Jehl, Raphael" sort="Clere Jehl, Raphael" uniqKey="Clere Jehl R" first="Raphaël" last="Clere-Jehl">Raphaël Clere-Jehl</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schenck, Malika" sort="Schenck, Malika" uniqKey="Schenck M" first="Malika" last="Schenck">Malika Schenck</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fagot Gandet, Florence" sort="Fagot Gandet, Florence" uniqKey="Fagot Gandet F" first="Florence" last="Fagot Gandet">Florence Fagot Gandet</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fafi Kremer, Samira" sort="Fafi Kremer, Samira" uniqKey="Fafi Kremer S" first="Samira" last="Fafi-Kremer">Samira Fafi-Kremer</name>
<affiliation wicri:level="3"><nlm:affiliation>ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Virologie Médicale, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Virologie Médicale, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Castelain, Vincent" sort="Castelain, Vincent" uniqKey="Castelain V" first="Vincent" last="Castelain">Vincent Castelain</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schneider, Francis" sort="Schneider, Francis" uniqKey="Schneider F" first="Francis" last="Schneider">Francis Schneider</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grunebaum, Lelia" sort="Grunebaum, Lelia" uniqKey="Grunebaum L" first="Lélia" last="Grunebaum">Lélia Grunebaum</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire de d'Hématologie, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de d'Hématologie, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Angles Cano, Eduardo" sort="Angles Cano, Eduardo" uniqKey="Angles Cano E" first="Eduardo" last="Anglés-Cano">Eduardo Anglés-Cano</name>
<affiliation wicri:level="3"><nlm:affiliation>Innovative Therapies in Haemostasis, INSERM UMR_S 1140, Université de Paris, 75006, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Innovative Therapies in Haemostasis, INSERM UMR_S 1140, Université de Paris, 75006, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sattler, Laurent" sort="Sattler, Laurent" uniqKey="Sattler L" first="Laurent" last="Sattler">Laurent Sattler</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire de d'Hématologie, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de d'Hématologie, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mertes, Paul Michel" sort="Mertes, Paul Michel" uniqKey="Mertes P" first="Paul-Michel" last="Mertes">Paul-Michel Mertes</name>
<affiliation wicri:level="3"><nlm:affiliation>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meziani, Ferhat" sort="Meziani, Ferhat" uniqKey="Meziani F" first="Ferhat" last="Meziani">Ferhat Meziani</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex, France. Ferhat.Meziani@chru-strasbourg.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>UMR 1260, Regenerative Nanomedicine (RNM), FMTS, INSERM (French National Institute of Health and Medical Research), Strasbourg, France. Ferhat.Meziani@chru-strasbourg.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMR 1260, Regenerative Nanomedicine (RNM), FMTS, INSERM (French National Institute of Health and Medical Research), Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Intensive care medicine</title>
<idno type="eISSN">1432-1238</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Anticoagulants (therapeutic use)</term>
<term>Betacoronavirus (pathogenicity)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (physiopathology)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Critical Illness (MeSH)</term>
<term>Female (MeSH)</term>
<term>Fibrin Fibrinogen Degradation Products (analysis)</term>
<term>Fibrin Fibrinogen Degradation Products (metabolism)</term>
<term>France (epidemiology)</term>
<term>Humans (MeSH)</term>
<term>Intensive Care Units (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (physiopathology)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Propensity Score (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Pulmonary Embolism (complications)</term>
<term>Pulmonary Embolism (mortality)</term>
<term>Pulmonary Embolism (physiopathology)</term>
<term>Pulmonary Embolism (virology)</term>
<term>Severe Acute Respiratory Syndrome (complications)</term>
<term>Severe Acute Respiratory Syndrome (mortality)</term>
<term>Severe Acute Respiratory Syndrome (physiopathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Thrombosis (etiology)</term>
<term>Thrombosis (mortality)</term>
<term>Thrombosis (physiopathology)</term>
<term>Thrombosis (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Anticoagulants (usage thérapeutique)</term>
<term>Betacoronavirus (pathogénicité)</term>
<term>Embolie pulmonaire (complications)</term>
<term>Embolie pulmonaire (mortalité)</term>
<term>Embolie pulmonaire (physiopathologie)</term>
<term>Embolie pulmonaire (virologie)</term>
<term>Femelle (MeSH)</term>
<term>France (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (physiopathologie)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Maladie grave (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (physiopathologie)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Produits de dégradation de la fibrine et du fibrinogène (analyse)</term>
<term>Produits de dégradation de la fibrine et du fibrinogène (métabolisme)</term>
<term>Score de propension (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Syndrome respiratoire aigu sévère (complications)</term>
<term>Syndrome respiratoire aigu sévère (mortalité)</term>
<term>Syndrome respiratoire aigu sévère (physiopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Thrombose (mortalité)</term>
<term>Thrombose (physiopathologie)</term>
<term>Thrombose (virologie)</term>
<term>Thrombose (étiologie)</term>
<term>Unités de soins intensifs (MeSH)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fibrin Fibrinogen Degradation Products</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fibrin Fibrinogen Degradation Products</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anticoagulants</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Produits de dégradation de la fibrine et du fibrinogène</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Pulmonary Embolism</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Thrombosis</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Pulmonary Embolism</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Thrombosis</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Embolie pulmonaire</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Thrombose</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Embolie pulmonaire</term>
<term>Produits de dégradation de la fibrine et du fibrinogène</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Embolie pulmonaire</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Thrombose</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Pulmonary Embolism</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Thrombosis</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticoagulants</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Embolie pulmonaire</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Thrombose</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pulmonary Embolism</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Thrombosis</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Thrombose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Humans</term>
<term>Intensive Care Units</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Propensity Score</term>
<term>Prospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Score de propension</term>
<term>Sujet âgé</term>
<term>Unités de soins intensifs</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b>
</p>
<p>Little evidence of increased thrombotic risk is available in COVID-19 patients. Our purpose was to assess thrombotic risk in severe forms of SARS-CoV-2 infection.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrome (ARDS) due to COVID-19 between March 3rd and 31st 2020 were included. Medical history, symptoms, biological data and imaging were prospectively collected. Propensity score matching was performed to analyze the occurrence of thromboembolic events between non-COVID-19 ARDS and COVID-19 ARDS patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>150 COVID-19 patients were included (122 men, median age 63 [53; 71] years, SAPSII 49 [37; 64] points). Sixty-four clinically relevant thrombotic complications were diagnosed in 150 patients, mainly pulmonary embolisms (16.7%). 28/29 patients (96.6%) receiving continuous renal replacement therapy experienced circuit clotting. Three thrombotic occlusions (in 2 patients) of centrifugal pump occurred in 12 patients (8%) supported by ECMO. Most patients (> 95%) had elevated D-dimer and fibrinogen. No patient developed disseminated intravascular coagulation. Von Willebrand (vWF) activity, vWF antigen and FVIII were considerably increased, and 50/57 tested patients (87.7%) had positive lupus anticoagulant. Comparison with non-COVID-19 ARDS patients (n = 145) confirmed that COVID-19 ARDS patients (n = 77) developed significantly more thrombotic complications, mainly pulmonary embolisms (11.7 vs. 2.1%, p < 0.008). Coagulation parameters significantly differed between the two groups.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore probably be suggested.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32367170</PMID>
<DateCompleted><Year>2020</Year>
<Month>06</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>46</Volume>
<Issue>6</Issue>
<PubDate><Year>2020</Year>
<Month>06</Month>
</PubDate>
</JournalIssue>
<Title>Intensive care medicine</Title>
<ISOAbbreviation>Intensive Care Med</ISOAbbreviation>
</Journal>
<ArticleTitle>High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.</ArticleTitle>
<Pagination><MedlinePgn>1089-1098</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-020-06062-x</ELocationID>
<Abstract><AbstractText Label="PURPOSE">Little evidence of increased thrombotic risk is available in COVID-19 patients. Our purpose was to assess thrombotic risk in severe forms of SARS-CoV-2 infection.</AbstractText>
<AbstractText Label="METHODS">All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrome (ARDS) due to COVID-19 between March 3rd and 31st 2020 were included. Medical history, symptoms, biological data and imaging were prospectively collected. Propensity score matching was performed to analyze the occurrence of thromboembolic events between non-COVID-19 ARDS and COVID-19 ARDS patients.</AbstractText>
<AbstractText Label="RESULTS">150 COVID-19 patients were included (122 men, median age 63 [53; 71] years, SAPSII 49 [37; 64] points). Sixty-four clinically relevant thrombotic complications were diagnosed in 150 patients, mainly pulmonary embolisms (16.7%). 28/29 patients (96.6%) receiving continuous renal replacement therapy experienced circuit clotting. Three thrombotic occlusions (in 2 patients) of centrifugal pump occurred in 12 patients (8%) supported by ECMO. Most patients (> 95%) had elevated D-dimer and fibrinogen. No patient developed disseminated intravascular coagulation. Von Willebrand (vWF) activity, vWF antigen and FVIII were considerably increased, and 50/57 tested patients (87.7%) had positive lupus anticoagulant. Comparison with non-COVID-19 ARDS patients (n = 145) confirmed that COVID-19 ARDS patients (n = 77) developed significantly more thrombotic complications, mainly pulmonary embolisms (11.7 vs. 2.1%, p < 0.008). Coagulation parameters significantly differed between the two groups.</AbstractText>
<AbstractText Label="CONCLUSION">Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore probably be suggested.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Helms</LastName>
<ForeName>Julie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tacquard</LastName>
<ForeName>Charles</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Severac</LastName>
<ForeName>François</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Groupe Méthodes en Recherche Clinique (GMRC), Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leonard-Lorant</LastName>
<ForeName>Ian</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ohana</LastName>
<ForeName>Mickaël</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Delabranche</LastName>
<ForeName>Xavier</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Merdji</LastName>
<ForeName>Hamid</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>UMR 1260, Regenerative Nanomedicine (RNM), FMTS, INSERM (French National Institute of Health and Medical Research), Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Clere-Jehl</LastName>
<ForeName>Raphaël</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schenck</LastName>
<ForeName>Malika</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fagot Gandet</LastName>
<ForeName>Florence</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fafi-Kremer</LastName>
<ForeName>Samira</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, LabEx TRANSPLANTEX, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Strasbourg, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratoire de Virologie Médicale, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Castelain</LastName>
<ForeName>Vincent</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schneider</LastName>
<ForeName>Francis</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive Réanimation, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grunebaum</LastName>
<ForeName>Lélia</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Laboratoire de d'Hématologie, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anglés-Cano</LastName>
<ForeName>Eduardo</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Innovative Therapies in Haemostasis, INSERM UMR_S 1140, Université de Paris, 75006, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sattler</LastName>
<ForeName>Laurent</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Laboratoire de d'Hématologie, Hautepierre, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mertes</LastName>
<ForeName>Paul-Michel</ForeName>
<Initials>PM</Initials>
<AffiliationInfo><Affiliation>Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meziani</LastName>
<ForeName>Ferhat</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, 1, Place de l'Hôpital, 67091, Strasbourg Cedex, France. Ferhat.Meziani@chru-strasbourg.fr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>UMR 1260, Regenerative Nanomedicine (RNM), FMTS, INSERM (French National Institute of Health and Medical Research), Strasbourg, France. Ferhat.Meziani@chru-strasbourg.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis)</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>05</Month>
<Day>04</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Intensive Care Med</MedlineTA>
<NlmUniqueID>7704851</NlmUniqueID>
<ISSNLinking>0342-4642</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000925">Anticoagulants</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005338">Fibrin Fibrinogen Degradation Products</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C036309">fibrin fragment D</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Intensive Care Med. 2020 Jul;46(7):1500-1501</RefSource>
<PMID Version="1">32435822</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000925" MajorTopicYN="N">Anticoagulants</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005338" MajorTopicYN="N">Fibrin Fibrinogen Degradation Products</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057216" MajorTopicYN="N">Propensity Score</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011655" MajorTopicYN="N">Pulmonary Embolism</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013927" MajorTopicYN="N">Thrombosis</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">ARDS</Keyword>
<Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">Coagulopathy</Keyword>
<Keyword MajorTopicYN="Y">Lupus anticoagulant</Keyword>
<Keyword MajorTopicYN="Y">Thrombosis</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>04</Month>
<Day>08</Day>
</PubMedPubDate>
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<Month>04</Month>
<Day>17</Day>
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<Month>5</Month>
<Day>6</Day>
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<affiliations><list><country><li>France</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Grand Est</li>
<li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
<li>Strasbourg</li>
</settlement>
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<tree><country name="France"><region name="Grand Est"><name sortKey="Helms, Julie" sort="Helms, Julie" uniqKey="Helms J" first="Julie" last="Helms">Julie Helms</name>
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<name sortKey="Angles Cano, Eduardo" sort="Angles Cano, Eduardo" uniqKey="Angles Cano E" first="Eduardo" last="Anglés-Cano">Eduardo Anglés-Cano</name>
<name sortKey="Castelain, Vincent" sort="Castelain, Vincent" uniqKey="Castelain V" first="Vincent" last="Castelain">Vincent Castelain</name>
<name sortKey="Clere Jehl, Raphael" sort="Clere Jehl, Raphael" uniqKey="Clere Jehl R" first="Raphaël" last="Clere-Jehl">Raphaël Clere-Jehl</name>
<name sortKey="Clere Jehl, Raphael" sort="Clere Jehl, Raphael" uniqKey="Clere Jehl R" first="Raphaël" last="Clere-Jehl">Raphaël Clere-Jehl</name>
<name sortKey="Delabranche, Xavier" sort="Delabranche, Xavier" uniqKey="Delabranche X" first="Xavier" last="Delabranche">Xavier Delabranche</name>
<name sortKey="Fafi Kremer, Samira" sort="Fafi Kremer, Samira" uniqKey="Fafi Kremer S" first="Samira" last="Fafi-Kremer">Samira Fafi-Kremer</name>
<name sortKey="Fafi Kremer, Samira" sort="Fafi Kremer, Samira" uniqKey="Fafi Kremer S" first="Samira" last="Fafi-Kremer">Samira Fafi-Kremer</name>
<name sortKey="Fagot Gandet, Florence" sort="Fagot Gandet, Florence" uniqKey="Fagot Gandet F" first="Florence" last="Fagot Gandet">Florence Fagot Gandet</name>
<name sortKey="Grunebaum, Lelia" sort="Grunebaum, Lelia" uniqKey="Grunebaum L" first="Lélia" last="Grunebaum">Lélia Grunebaum</name>
<name sortKey="Helms, Julie" sort="Helms, Julie" uniqKey="Helms J" first="Julie" last="Helms">Julie Helms</name>
<name sortKey="Leonard Lorant, Ian" sort="Leonard Lorant, Ian" uniqKey="Leonard Lorant I" first="Ian" last="Leonard-Lorant">Ian Leonard-Lorant</name>
<name sortKey="Merdji, Hamid" sort="Merdji, Hamid" uniqKey="Merdji H" first="Hamid" last="Merdji">Hamid Merdji</name>
<name sortKey="Merdji, Hamid" sort="Merdji, Hamid" uniqKey="Merdji H" first="Hamid" last="Merdji">Hamid Merdji</name>
<name sortKey="Mertes, Paul Michel" sort="Mertes, Paul Michel" uniqKey="Mertes P" first="Paul-Michel" last="Mertes">Paul-Michel Mertes</name>
<name sortKey="Meziani, Ferhat" sort="Meziani, Ferhat" uniqKey="Meziani F" first="Ferhat" last="Meziani">Ferhat Meziani</name>
<name sortKey="Meziani, Ferhat" sort="Meziani, Ferhat" uniqKey="Meziani F" first="Ferhat" last="Meziani">Ferhat Meziani</name>
<name sortKey="Ohana, Mickael" sort="Ohana, Mickael" uniqKey="Ohana M" first="Mickaël" last="Ohana">Mickaël Ohana</name>
<name sortKey="Sattler, Laurent" sort="Sattler, Laurent" uniqKey="Sattler L" first="Laurent" last="Sattler">Laurent Sattler</name>
<name sortKey="Schenck, Malika" sort="Schenck, Malika" uniqKey="Schenck M" first="Malika" last="Schenck">Malika Schenck</name>
<name sortKey="Schneider, Francis" sort="Schneider, Francis" uniqKey="Schneider F" first="Francis" last="Schneider">Francis Schneider</name>
<name sortKey="Severac, Francois" sort="Severac, Francois" uniqKey="Severac F" first="François" last="Severac">François Severac</name>
<name sortKey="Tacquard, Charles" sort="Tacquard, Charles" uniqKey="Tacquard C" first="Charles" last="Tacquard">Charles Tacquard</name>
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   |texte=   High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.
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High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.

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